Journal: NeuroImage : Clinical

Article Title: Subthalamic oscillatory activity and connectivity during gait in Parkinson's disease

doi: 10.1016/j.nicl.2018.05.001

Figure Lengend Snippet: A. Group shank rotation velocity. Gait cycle is epoched between the peak of the shank rotational velocity of one leg and the following peak of the same leg. Average contains epochs starting with left (e.g. Supplementary Fig. 3E) and right legs (e.g. Supplementary Fig. 3F). B, C. Time-frequency group analysis showing gait cycle locked modulation in relation to average resting using “contralateral averaging”. While high beta frequency power is attenuated across the gait cycle, low frequencies show increases. Frequencies between 8 and 20 Hz do show increases in power in the double support periods of the gait-cycle. C. Group z-statistics for comparison between gait and rest showing significant decreases in power during gait in the high beta range (20–30 Hz) across the whole gait-cycle. Non significant z-values are zeroed out.

Article Snippet: To find bursts, we marked each peak of the average high beta amplitude envelope (Matlab function findpeaks) and averaged across all bursts from each nucleus and condition using the timeframe of ±30 ms around the peak.

Techniques: Comparison

Journal: NeuroImage : Clinical

Article Title: Subthalamic oscillatory activity and connectivity during gait in Parkinson's disease

doi: 10.1016/j.nicl.2018.05.001

Figure Lengend Snippet: Oscillatory bilateral STN frequency power, connectivity and burst analysis. A. Group relative power spectrum showing a significant difference in the high beta band 20–30 Hz. High beta power during sitting and standing rest is comparable and is attenuated during normal and slow gait. B. Group amplitude envelope correlations across frequencies between left and right STN showing significant differences between rest and gait in the high beta band. C. LWR of oscillatory bursts across frequencies during gait and sitting rest showing significant differences in the high beta band. Lifetimes of beta bursts are prolonged during rest and waiting-times are shortened as compared to gait. D. Shape of high beta bursts during rest and gait showing higher peak amplitudes and narrow in regard to burst width during rest as compared to gait. Shaded error bars indicate SEM.

Article Snippet: To find bursts, we marked each peak of the average high beta amplitude envelope (Matlab function findpeaks) and averaged across all bursts from each nucleus and condition using the timeframe of ±30 ms around the peak.

Techniques:

Journal: NeuroImage : Clinical

Article Title: Subthalamic oscillatory activity and connectivity during gait in Parkinson's disease

doi: 10.1016/j.nicl.2018.05.001

Figure Lengend Snippet: A, B. Time-frequency group analysis showing gait cycle locked amplitude envelope modulation in relation to average gait baseline in alpha, beta and gamma frequencies using contralateral and ipsilateral averaging methods. For the average difference in A. signals from the left STN are used in epochs locked to right leg shank rotation peaks and right STN LFP in epochs beginning with the left foot (contralateral averaging). In B., the same analysis is presented, but using right STN LFPs for epochs which begin with right leg movement and vice versa (ipsilateral averaging).

Article Snippet: To find bursts, we marked each peak of the average high beta amplitude envelope (Matlab function findpeaks) and averaged across all bursts from each nucleus and condition using the timeframe of ±30 ms around the peak.

Techniques: